Effect of Bio-Oss® Collagen and Collagen Matrix on Bone Formation

OBJECTIVE to compare the amount of new bone produced by Bio-Oss((R)) Collagen to that produced by collagen matrix in vivo. METHOD eighteen bone defects, 5mm by 10mm were created in the parietal bone of 9 New Zealand White rabbits. 6 defects were grafted with Bio-Oss((R)) Collagen. 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis. RESULTS A total of 339% more new bone was present in defects grafted with Bio-Oss((R)) Collagen than those grafted with collagen matrix (positive control). No bone was formed in the negative control group. CONCLUSION Bio-Oss((R)) Collagen has the effect of stimulating new bone formation locally compared with collagen matrix in vivo. Bio-Oss((R) )Collagen may be utilized as a bone graft material.